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Slow-release capsule for reducing winter scours in sheep Stage: proof of concept
The potential for continuous Trichostrongylus antigen administration to sheep as a means to prevent hypersensitivity scours following infection was investigated. The results of the trial demonstrate continuous administration of parasite antigen leads to a suppression of the eosinophil response in the sheep following parasite challenge. This eosinophil suppression correlated with a significantly higher worm count in the antigen treated group. Despite being challenged with 7000 L3s, neither treated nor untreated sheep developed scours, indicating the development of diarrhoea is a multifactorial process. Although scouring did not occur in sheep in this trial following challenge, the suppression of eosinophils, the main mechanism behind the development of immune mediated scouring in sheep, indicates that the continuous administration of low doses of parasite antigen to sheep has the potential to prevent or reduce hypersensitivity diarrhoea in sheep. This concept may serve as a basis development of a commercial intra-ruminal device to prevent scouring in sheep.
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Slow-release capsule for reducing winter scours in sheep – STAGE 1: Proof of Concept
This page was last updated on 05/07/2018
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