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Development of assays and assessment of oral bioavailability of the NSAIDs ketoprofen, carprofen and flunixin in sheep
A sensitive and selective analytical method for the determination of ketoprofen, carprofen, flunixin and metabolite 5-hydroxyflunixin in ovine plasma was developed and validated. Sheep were randomised into 4 treatment groups, with a placebo group receiving saline and 3 groups given NSAIDs orally for 6 days. NSAIDs were given at approximately double the dose rate used for non-parenteral administration to cattle and previously used experimentally in sheep every 24 hours: carprofen (8.0 mg/kg), ketoprofen (8.0 mg/kg) and flunixin (4.0 mg/kg). Carprofen, ketoprofen and flunixin were all present in ovine plasma two hours after oral administration, with averages between 4.5 - 8.4µg/mL for ketoprofen, 2.6 - 4.1µg/mL for flunixin, 0.1 - 0.78µg/mL for 5-hydroxyflunixin and 30 - 80µg/mL for carprofen. NSAID concentrations dropped 24 h after administration. The three NSAIDs were bioavailable in sheep two hours after oral administration with carprofen and flunixin reaching inferred therapeutic concentrations in blood by this time.
This page was last updated on 25/07/2017
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