Importation of Dam attenuated S. Typhimurium as a modified live vaccine for adult ruminants
Project start date: | 15 May 2014 |
Project end date: | 01 June 2015 |
Publication date: | 01 June 2015 |
Project status: | Completed |
Livestock species: | Sheep, Goat, Lamb, Grassfed cattle, Grainfed cattle |
Summary
The LEP R&D program has invested significantly into the construct of a Salmonella deletion. This requires that the new construct be imported from the US to Australia and undergo AQIS/OGTR inspection review prior to initiating safety studies and field trials. The first stages of this project include the application for importation of the vaccine construct and application for an in vivo usage permit. Once the vaccine has been imported into Australia, it is anticipated that an industry partner will then produce the vaccine in bulk such that safety and efficacy testing can be initiated in sheep using the new, reformulated construct in a commercial formulation to achieve vaccine registration.